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Risk-Stratified Monitoring of Open Angle Glaucoma Suspects Based on Diagnostic Conversion Risk

Primary open angle glaucoma (POAG) is the leading cause of irreversible vision loss worldwide affecting an estimated 53 million people in 2020 and projected 80 million people by 2040.1 In the United States (US), POAG is the most common subtype of glaucoma affecting approximately 1.4% to 6.8% of adults over 40 years of age.2 Due to the ocular morbidity and public health impact of POAG, individuals exhibiting risk factors during routine eye exams, such as elevated intraocular pressure (IOP) or enlarged cup to disc ratio (CDR), are diagnosed as open angle glaucoma suspects (OAGS) and undergo long-term monitoring for conversion to POAG.

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Subclinical Peripheral Vascular Leakage in Demyelinating Disease-Associated Uveitis

Uveitis associated with demyelinating diseases, particularly multiple sclerosis (MS), most frequently presents as an intermediate uveitis or pars planitis.1-4 This subset of ocular inflammation follows a chronic, indolent course that often results in cumulative structural complications such as chronic cystoid macular edema, epiretinal membrane (ERM), and secondary neovascularization. Recent epidemiological updates from 2025 indicate that the burden of MS-associated uveitis is significant and increasing, necessitating more precise monitoring strategies.

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Immune Checkpoint Inhibitor–Associated Uveitis: Insights From Comparative Analyses Across Malignancies and Drug Classes

Immune checkpoint inhibitors (ICIs) have transformed the treatment of multiple malignancies, improving survival across melanoma, nonsmall cell lung cancer, and several other tumor types.1-4 Despite these benefits, ICIs can trigger immune-related adverse events (irAEs) that reflect dysregulated immune activation.5,6 Ocular irAEs, such as noninfectious uveitis (NIU), are uncommon but potentially vision-threatening. The American Society of Clinical Oncology highlights that NIU occurs in approximately 1% of patients receiving ICIs, with a potentially higher incidence in those on combination regimens.

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Conjunctival Biopsy in Ocular Mucous Membrane Pemphigoid

Ocular mucous membrane pemphigoid (oMMP) is a chronic autoimmune disorder that manifests primarily as progressive conjunctival scarring. We reviewed the published literature on the role of conjunctival biopsy in oMMP.

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Vitrectomy Versus Observation for Lamellar Macular Holes With Epiretinal Proliferation: A Systematic Review and Meta-Analysis

To compare the visual and anatomical outcomes of vitrectomy with those of observation in eyes with lamellar macular holes associated with epiretinal proliferation (LHEP).

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Implementing Community-Based Adult Eye Screening in the United States: A CFIR-Guided Qualitative Study

Over the past century, community eye disease screening in the United States has evolved alongside shifting public health needs, medical progress, and persistent disparities. In the early 1900s, screening efforts focused on trachoma and were driven by federal immigration laws that mandated screening and denied entry into the US to those infected.1 These regulations led to the development of trachoma hospitals and mobile clinics, laying the foundation for community-based eye care. Around the same time, school vision screenings emerged and expanded nationwide.

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Risk of Retinal Detachment After Intravitreal Injection of Anti-VEGF: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis evaluated the literature-pooled risk of retinal detachment (RD) following intravitreal injection (IVI) of anti–vascular endothelial growth factor (anti-VEGF) agents.