#EndoSky

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Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications

Puberty is a major maturational event; its mechanisms and timing are driven by genetic determinants, but also controlled by endogenous and environmental cues. Substantial progress towards elucidation ...

thelancet.com

Less can be more: the 2026 Endocrine Society Guideline for precision care in central precocious puberty

Central precocious puberty (CPP) is a condition familiar to paediatric endocrinologists worldwide, the incidence of which has increased markedly over the past two decades, especially over the COVID-19...

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Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study

Longitudinal 1-mg DST changes are common. MACS-to-MACS patients had worsening hypertension, but rates of mortality and cardiovascular or thrombotic events were not significantly associated with 1-mg D...

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Secondary causes of diabetes: a crossroad of endocrinology and oncology

Cancer and diabetes share a bidirectional relationship, with cancer increasingly recognised as an associated factor of diabetes, both from the disease itself and its treatments. In this Review, we aim...

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Sweden plans to restrict PFAS

On July 23, 2026, the Government of Sweden announced plans to prohibit perfluoroalkyl and polyfluoroalkyl substances (PFAS), also called forever chemicals, in certain consumer products such as clothin...

www.thelancet.com

Less can be more: the 2026 Endocrine Society Guideline for precision care in central precocious puberty

Central precocious puberty (CPP) is a condition familiar to paediatric endocrinologists worldwide, the incidence of which has increased markedly over the past two decades, especially over the COVID-19...

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A novel homozygous thyroglobulin gene variant presenting with massive congenital goiter and neonatal airway obstruction

A novel homozygous TG gene variant was identified in a newborn baby who presented with severe respiratory failure and perinatal asphyxia secondary to tracheal compression caused by a massive…

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Rare causes of exogenous Cushing’s Syndrome: a challenge for endocrinologists

Exogenous Cushing syndrome is typically caused by therapeutic glucocorticoids, but adulterated natural remedies, compounds with intrinsic glucocorticoid-like activity, and factitious glucocorticoid…

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Intermittent fasting to treat diabetes: time to update clinical practice guidelines

Intermittent fasting is now the third most commonly practiced diet in the USA. Yet, despite more than 225 clinical trials—including nearly 40 in patients with diabetes or prediabetes—intermittent fast...

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Cardiovascular outcomes and mortality risk at diagnosis of type 2 diabetes in older adults: a retrospective population-based study using health records from Spain

Diabetes-associated relative excess risks for cardiovascular outcomes and mortality differed by age at first recorded type 2 diabetes diagnosis, with lower relative excess risks among those diagnosed ...