#drugdevelopment is an active hashtag on Bluesky. In the last 30 days, 20 people shared 67 posts with it — around 2 a day. Activity is down 29% versus the previous week, peaking on Sep 3 with 6 posts.

Posts with #drugdevelopment

Tatiana Prowell, MD

@tmprowell.bsky.social

over 1 year ago

A very cool thing about getting older in medicine: eventually you see a dreaded disease of your early career succumb to science. Once you witness it a few times, nothing will seem impossible to you in the same way ever again. #MedSky #DrugDevelopment

7 17 107

Tatiana Prowell, MD

@tmprowell.bsky.social

over 1 year ago

#MedSky The EMA, the #regulatory equivalent to FDA for the European Union, has moved from Twitter to BlueSky: @ema.europa.eu. They’re a great source of info on #publichealth, #drugdevelopment, & more.

media.tenor.com

a man is looking at his cell phone with a follow button in the background .

ALT: a man is looking at his cell phone with a follow button in the background .

3 31 62

Tatiana Prowell, MD

@tmprowell.bsky.social

almost 2 years ago

📣 NEW study compares #LongCovidKids to kids fully recovered from #COVID19 & uninfected controls: kids w/ #LongCovid have impaired neutrophil function w/ ⬇️ superoxide activity & phagocytosis. Symptoms correlated w/ defect. #MedSky #IDSky #PedSky #DrugDevelopment www.nature.com/articles/s41...

0 19 61

Tatiana Prowell, MD

@tmprowell.bsky.social

almost 2 years ago

NEW #Oncology: EGFR expression mediates resistance to T-DXd (EGFR overexpression ⬇️ HER2 homodimerization & HER2/ADC internalization) Combining with EGFR mAbs restored HER2/ADC trafficking & ⬆️ activity in nonclinical models #DrugDevelopment #OncoSky www.cell.com/cell-reports...

www.cell.com

EGFR-directed antibodies promote HER2 ADC internalization and efficacy

Gupta et al. demonstrate that high EGFR expression mediates resistance to HER2 antibody drug conjugates (ADCs) including trastuzumab deruxtecan (T-DXd) by limiting HER2/ADC internalization. The additi...

3 13 52

Tatiana Prowell, MD

@tmprowell.bsky.social

almost 2 years ago

#SABCS24 I’ll be speaking on Designing Patient-Centric #clinicaltrials. Join us Tues 12/10 2:30-4p CST! Thanks to my #bcsm #advocacy friends who weighed in. People w/ cancer & caregivers, what makes you join a trial (or not)? #PatientExperience bit.ly/4iknAnl #OncoAlert #OncSky #DrugDevelopment

2 13 50

Tatiana Prowell, MD

@tmprowell.bsky.social

over 1 year ago

#MedSky #OncSky #IDSky #DrugDevelopment #MedEd If you want to get up to speed on the #microbiome in #cancer literature, this review is an excellent summary. jamanetwork.com/journals/….

jamanetwork.com

The Microbiome and Cancer: A Review

This review in the Translational Science series summarizes current evidence regarding the human microbiome and cancer, including how the microbiota in the gut and other anatomical locations affect can...

4 9 46

Tatiana Prowell, MD

@tmprowell.bsky.social

about 1 year ago

#MedSky #IDSky 📢 Prospective cohort study (CO-FLOW) of adults hospitalized for #COVID19 finds only 1 in 8 fully recovered at 3m, & only 1 in 4 at 3y. More than half had ⬇️ memory & concentration at 3y. This is #LongCovid. HUGE unmet #DrugDevelopment need. www.thelancet.com/action/….

1 20 45

Tatiana Prowell, MD

@tmprowell.bsky.social

over 1 year ago

#MedSky #STEM #DrugDevelopment Poll of 1630 biomedical scientists from 80 countries finds ~3/4 believe there is a reproducibility crisis in science stemming mostly from pressure to publish. That should worry all of us for reasons of integrity & use of resources. www.nature.com/articles/d41...

www.nature.com

‘Publish or perish’ culture blamed for reproducibility crisis

Survey of more than 1,600 biomedical researchers also flagged small sample sizes and cherry-picking of data as leading causes of reproducibility problems.

0 11 42

Tatiana Prowell, MD

@tmprowell.bsky.social

almost 2 years ago

#OncSky #DrugDevelopment ⬇️⬇️⬇️

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social

Wow—one of the most impressive bench-to-bedside stories you’re ever going to see out today @Nature Spatial proteomics of potentially fatal toxic epidermal necrolysis/Stevens-Johnson Syndrome drug reactions identifies JAK/STAT pathway inhibition as effective therapy! www.nature.com/articles/s41...

1 7 30

Hans Clevers

@hansclevers.bsky.social

almost 2 years ago

Excited to join BlueSky! Will share insights in #intestine #stemcells #cancer #organoids #drugdevelopment and others. Blue image credentials: Luminal surface of the small intestine, Anne Rios. Goblet cells red, enterocytes blue

0 0 26

Tatiana Prowell, MD

@tmprowell.bsky.social

almost 2 years ago

#DrugDevelopment “Uncovering the anatomic & biological intricacies of residual disease will allow for ⬆️ precision in postneoadjuvant treatments, moving beyond the binary paradigm of RD vs path CR, toward more tailored rescue strategies.” 💯 #OncoSky #MedSky #bcsm jamanetwork.com/journals/….

jamanetwork.com

Heterogeneity of Residual Disease After Neoadjuvant Systemic Therapy in Breast Cancer

This review analyzes the heterogeneity of residual disease after neoadjuvant systemic therapy in patients with breast cancer.

2 4 26

Tatiana Prowell, MD

@tmprowell.bsky.social

over 1 year ago

#MedSky #IDSky #COVID19 #DrugDevelopment NEW A loss-of-function variant in PTPN2 assoc w/ #autoimmune disease incl #IBD can ⬆️ expression of ACE2 receptor via ⬆️ JAK-STAT signaling, making cells more prone to #SARSCoV2 invasion. Reversible w/ JAK inhibition. www.sciencedirect.com/sci….

www.sciencedirect.com

Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene

Coronavirus disease (COVID-19), caused by SARS-CoV-2, triggered a global pandemic with severe medical and socioeconomic consequences. While fatality r…

0 5 24