#Pharmsky is an active hashtag on Bluesky. In the last 30 days, 23 people shared 601 posts with it — around 20 a day. Activity is down 12% versus the previous week, peaking on Jul 22 with 27 posts.
Tags most often used together with #Pharmsky.
www.nature.com
Everyday painkiller made from plastic — by E. coli
Study highlights potential for sustainable synthesis of paracetamol.
doi.org
Enhancing immunity during ageing by targeting interactions within the tissue environment | Nature Reviews Drug Discovery
Immunity declines with age. This results in a higher risk of age-related diseases, diminished ability to respond to new infections and reduced response to vaccines. The causes of this immune dysfunction are cellular senescence, which occurs in both lymphoid and non-lymphoid tissue, and chronic, low-grade inflammation known as ‘inflammageing’. In this Review article, we highlight how the processes of inflammation and senescence drive each other, leading to loss of immune function. To break this cycle, therapies are needed that target the interactions between the altered tissue environment and the immune system instead of targeting each component alone. We discuss the relative merits and drawbacks of therapies that are directed at eliminating senescent cells (senolytics) and those that inhibit inflammation (senomorphics) in the context of tissue niches. Furthermore, we discuss therapeutic strategies designed to directly boost immune cell function and improve immune surveillance in tissue
www.bbc.com
Measles: The race to understand 'immune amnesia'
Scientists have known for years that measles can alter the immune system – but the latest evidence suggests it's less of a mild tweaking, and more of a total reset.
academic.oup.com
You’ve Got a Friend in Me: Curbside Questions Infectious Diseases Clinicians Ask Infectious Diseases Pharmacists
doi.org
Gut microbiota strain richness is species specific and affects engraftment | Nature
Despite the fundamental role of bacterial strain variation in gut microbiota function1–6, the number of unique strains of a species that can stably colonize the human intestine is still unknown for almost all species. Here we determine the strain richness (SR) of common gut species using thousands of sequenced bacterial isolates with paired metagenomes. We show that SR varies across species, is transferable by faecal microbiota transplantation, and is uniquely low in the gut compared with soil and lake environments. Active therapeutic administration of supraphysiologic numbers of strains per species increases recipient SR, which then converges back to the population average after dosing is ceased. Stratifying engraftment outcomes by high or low SR shows that SR predicts microbial addition or replacement in faecal transplants. Together, these results indicate that properties of the gut ecosystem govern the number of strains of each species colonizing the gut and thereby influence strain
www.cell.com
https://www.cell.com/cell/fulltext/S0092-8674(26)00519-2
No description available
www.cell.com
https://www.cell.com/cell/fulltext/S0092-8674(26)00275-8
No description available
www.cell.com
https://www.cell.com/ajhg/fulltext/S0002-9297(26)00196-5
No description available
www.cell.com
https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6
No description available
www.cell.com
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
https://www.cell.com/cell/fulltext/S0092-8674(26)00511-8
No description available
doi.org
Leveraging nanoparticle protein corona to advance plasma proteome profiling | Nature Communications
The blood plasma proteome is a rich reservoir of potential biomarkers, yet its analysis is hindered by a protein concentration dynamic range exceeding ten orders of magnitude. Traditional fractionation and enrichment methods often present limitations in detecting rare proteins masked by the presence of abundant proteins. A promising frontier technology has emerged to overcome such limitations: leveraging nanoparticle protein coronas to enrich low-abundance plasma proteins and unveil previously inaccessible layers of the proteome. This Perspective highlights the capabilities of the protein corona technology in enhancing proteome coverage, addresses its current limitations and outlines future directions in proteoform analysis and causal inference. Proteomics has long suffered from artifacts and effects due to the wide range of protein concentrations. Here, the authors offer a perspective on the use of nanoparticles to enhance the detection of low-abundance proteins by using the formation
www.cell.com
https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7
No description available
doi.org
Cell polarity control by an unconventional G-protein complex in bacteria | Nature Communications
In Myxococcus xanthus, a predatory soil bacterium, cell polarity and motility are regulated by MglA (a small GTPase) and its regulators, MglB (a potential GAP) and RomRX (a previously proposed GEF), but their precise roles remain unclear. Using fluorescent nucleotides suitable for fluorescence anisotropy measurements, we show that RomRX does not function as a GEF but instead acts as an effector binding MglAGTP. We further find, using an enzymatic model, that MglB exhibits both GAP and GEF properties depending on the local MglAGDP concentration. Additionally, RomRX, specifically RomR, effectively dissociates the MglA-MglB complex by sequestering MglB. This low-affinity interaction permits GAP activity while still partitioning the proteins in vivo, as shown by a biomimetic oil-emulsion droplet assay in a cell-sized system. A minimal mathematical model incorporating these interactions and previous findings recapitulates how dynamic interactions between these three players form an invertib
www.cell.com
https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9
No description available
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