#Osteoarthritis is an active hashtag on Bluesky. In the last 30 days, 28 people shared 41 posts with it — around 1 a day. Activity is up 67% versus the previous week, peaking on Jul 16 with 4 posts.

Posts with #Osteoarthritis

Skydog Sanctuary

@skydogsanctuary.bsky.social

10 months ago

Severe #osteoarthritis makes it impossible for Eloise to run wild with our #burro herd. But #donkeys have their size and amazing healing abilities in their favor. We’ve seen miracles with our #longears. We are keeping her comfortable as she gets lots of stall rest, love, care, and good nutrition.

4 17 163

Carol Hedges

@riotgrandma.bsky.social

over 1 year ago

❤️💀❤️💀❤️💀❤️💀❤️ My STICK has arrived! #osteoarthritis #disabled

16 2 89

Carol Hedges

@riotgrandma.bsky.social

over 1 year ago

😹👊🏻😹👊🏻😹👊🏻😹👊🏻😹 In anticipation of my return to the public sphere I have just ordered this! not just a walking aid stick but a poking racists stick and a clonking anyone who annoys me stick Beware the armed crone! #osteoarthritis #arthritis #oldie

17 7 83

Mel’s

@melanpops.bsky.social

over 1 year ago

For anyone who understands this 💜 #spoonie #disability #migraine #fibro #osteoarthritis

Picture says why do I post about my illness?
Because if one person feels less alone it gives my pain purpose

3 4 82

Bobbi Elman

@autismadvocate.co.uk

over 1 year ago

#Facts 😂🤣😂 #AuDHD #EhlersDanlos #PoTS #Osteoarthritis #Thyroidectomy #Cataracts ( thanks steroids ) Etc etc etc

4 7 65

A.K.F. (he/him)

@akfullerton.bsky.social

4 months ago

GIFT ARTICLE With funding from ARPA-H, three teams of researchers have regrown bone and cartilage, even entire knees, in animal studies. Human trials are not far off. #osteoarthritis www.nytimes.com/2026/04/0….

www.nytimes.com

Federal Agency Unveils Three Potential Osteoarthritis Treatments

0 30 59

Oden

@oden-gjallarhornet.bsky.social

about 1 month ago

Single Injection Reverses #Osteoarthritis in Animals in Just 4 Weeks www.sciencealert.com/sing….

www.sciencealert.com

Single Injection Reverses Osteoarthritis in Animals in Just 4 Weeks

The chronic loss of joint cartilage known as osteoarthritis causes pain and bone decay for hundreds of millions of people every day.

0 4 42

Ewan St. John Smith

@psalmotoxin.bsky.social

over 1 year ago

Cool overview of #osteoarthritis, which will be of interest to many in #neuroskyence & #PainResearch communities. Thanks to @tuhinaneogi.bsky.social, @jointsintheworld.bsky.social & others! Some figures that will doubtless appear in many talks in years to come! www.nature.com/articles/s41...

This figure shows the healthy joint (part a) and osteoarthritic joint (part b). Almost all tissue structures in osteoarthritis joint tissues show pathological changes, including articular cartilage degradation, fibrosis and inflammation of the synovium and infrapatellar fat pad, subchondral bone remodelling, meniscal damage and ligament damage.

This figure outlines the hierarchical relationship between individual-level (influenced by genetic, systemic and lifestyle factors) and joint-level (specific to joint anatomy and function) risk factors that contribute to the susceptibility, progression and burden of osteoarthritis. Modifiable risk factors (blue) and non-modifiable risk factors (red) are also displayed.

Knee osteoarthritis is one of the most common joint diseases, characterized by pathological changes that involve the degradation of articular cartilage, inflammation and fibrosis of the synovium and infrapatellar fat pad, and remodelling of the subchondral bone. Cartilage degradation is driven by the excessive activity of matrix metalloproteinases (MMPs) and ADAMTS enzymes, leading to the breakdown of collagen and proteoglycans, resulting in cartilage becoming thinner and cracked, compromising its cushioning function, and causing joint pain and stiffness. Meanwhile, synovial tissue shows chronic inflammation, including congestion, synovial cell hyperplasia and inflammatory cell infiltration, increasing inflammatory factors in the synovial fluid and further damaging the cartilage. The infrapatellar fat pad is also affected, with fibrosis potentially altering mechanical properties around the joint, affecting movement. The subchondral bone undergoes significant structural changes such as sclerosis and abnormal remodelling, which can lead to osteophyte formation, altering joint mechanics and increasing cartilage load. The sclerosis changes stress distribution within the joint, exacerbating cartilage damage. These pathological processes are interconnected, forming a complex network where inflammatory factors, such as IL-1β, IL-6 and TNF, further promote cartilage degradation and synovial inflammation. Mechanical stress signals activate chondrocytes and bone cells, accelerating lesion progression. Senescence-associated secretory phenotype (SASP) factors from chondrocytes or matrix-degrading enzymes secreted by osteoclasts and synovium/fat pad cells interact to exacerbate tissue damage, highlighting the importance of understanding these cellular and molecular interactions for effective osteoarthritis treatment. ARGS, aggrecanase generated aggrecan amino acids alanine, arginine, glycine, serine.

a, Overview of the peripheral pain pathway in joint pain. Noxious stimuli activate the peripheral terminals of nociceptors that innervate joint tissues. Depolarization of nerve terminals initiates the firing of action potentials that invade the dorsal root ganglia, where the cell bodies reside. This requires the activation of voltage-gated sodium channels NaV1.7, NaV1.8 and NaV1.9. Signals are transmitted to the dorsal horn of the spinal cord, where nociceptors synapse with second-order neurons — either interneurons (not shown) or projection neurons that cross to the contralateral side and carry the signal up the spinal cord. From there, the signals are propagated to higher regions of the central nervous system and different areas of the brain, where they are perceived as pain. b, Peripheral terminals of nociceptors express voltage-gated sodium channels and ion channels, such as TRPV1, or mechanosensitive ion channels such as Piezo2. They also express receptors for inflammatory mediators released by degrading and inflamed joint tissues, such as nerve growth factor (NGF), CCL2 or disease-associated molecular patterns (DAMPs). c, Anatomical neuroplasticity occurs as part of osteoarthritis pathology, including neo-innervation of the synovium and sprouting of nociceptors in the subchondral bone, which may breach the tidemark.

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Jenbo 💙💙

@jenbo.bsky.social

about 5 hours ago

Gah! Left wrist and thumb X-rays reveal severe osteoarthritis. Yay. What helps you deal with it? Diet? Meds? Avoiding gluten? Anything? #Osteoarthritis

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