#medicinalchemistry is an active hashtag on Bluesky. In the last 30 days, 8 people shared 10 posts with it — around 0 a day. Activity is down 75% versus the previous week, peaking on Jul 30 with 3 posts.
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How an HIV Miracle Drug Vanished
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dlvr.it
Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST - Nature Communications
In this work, the authors develop and characterize KIT/PDGFRA inhibitors to define key molecular interactions underlying inhibitor selectivity and drug-resistance, reporting structural insights for targeting solvent-front mutations across oncogenic kinases.
advanced.onlinelibrary.wiley.com
Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice
Herein we report a boron-based pyrazole, (Borsantrazole - a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset,...
cen.acs.org
Reaction rounds up atoms into unusual cyclic compounds
Chiral aromatic heterocycles could be novel motifs in drug candidates
dlvr.it
Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST - Nature Communications
In this work, the authors develop and characterize KIT/PDGFRA inhibitors to define key molecular interactions underlying inhibitor selectivity and drug-resistance, reporting structural insights for targeting solvent-front mutations across oncogenic kinases.
advanced.onlinelibrary.wiley.com
Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice
Herein we report a boron-based pyrazole, (Borsantrazole - a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset,...
cen.acs.org
Reaction rounds up atoms into unusual cyclic compounds
Chiral aromatic heterocycles could be novel motifs in drug candidates
www.xiahepublishing.com
Proposal on Future Drug Development of Novel 1,2,3-Triazole-Urea Hybrids
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www.tandfonline.com
A multipurpose probe for identification and mechanistic analysis of prenylation inhibitors
Protein prenylation is a critical post-translational modification that controls many cancer-related signalling pathways and represents an important therapeutic target currently lacking effective ph...
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Pharm2Market | Business Intelligence for Biotechs
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