#legionella is an active hashtag on Bluesky. In the last 30 days, 9 people shared 30 posts with it — around 1 a day. Activity is up 200% versus the previous week, peaking on Aug 25 with 4 posts.

Posts with #legionella

Eduardo Rocha

@epcrocha.bsky.social

almost 3 years ago

New preprint on the evolution of natural transformation. We measured transformation rates in 100s of #Acinetobacter baumannii & #Legionella pneumophila. Key arising question: why are so many strains non-transformable if the many recent transitions to non-transformability seem deleterious? 1/4

www.biorxiv.org

Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of ...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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Green Lab JHMI

@greenlab.bsky.social

2 months ago

Wait, what?! This isn’t about ribosomes? Check out our new work where we find that a #Legionella effector thought to target host translation instead targets metabolism by modifying a host glycolytic metabolite. Led by @drjoshblack.bsky.social www.cell.com/molecular-ce...

www.cell.com

The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate

Black et al. identify the L. pneumophila effector SidL as an adenylyltransferase that targets host glycolysis. SidL covalently modifies the glycolytic intermediate 3-phosphoglycerate (3PG) with AMP, g...

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Jonathan Ryder, MD

@jonathanrydermd.bsky.social

7 months ago

New from @cidjournal.bsky.social and Mayo Clinic, a modern cohort of Legionella PNA: 344 adults with Legionella (85% L pneumophila) 1/3rd ICU, 1/8 died at 30 days Urine Ag only + test in 42.4%, but among those with +PCR/Cx, UAg+ in only 25.6% #IDSky #Legionella academic.oup.com/cid/adva….

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CIDRAP

@cidrap.bsky.social

7 months ago

#Legionella pneumonia tied to high death rates, especially in older patients with underlying conditions Most patients in the study (94%) were hospitalized, and the 30-day death rate was 12%. www.cidrap.umn.edu/l... Photo: Christina Spicuzza / Flickr cc

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Alex Ensminger

@legionella.bsky.social

about 1 year ago

Sorry for the late reply ‪@superbug-slayer.bsky.social ‪@roblavigne.bsky.social‬. Here's a Legionella phage & it likely shaped the emergence of Legionnaires' in the first place! www.science.org/doi/10.11…. (cryoEM w/ @smlea.bsky.social @justindeme.bsky.social). #phage #legionella #legionnaires

A Twitter conversation from 2019 in search of the elusive Legionella phages.

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Daily Alpine

@dailyalpine.com

1 day ago

Linz prosecutors investigate deaths after Legionella outbreak #Austria #legionella #Linz

www.dailyalpine.com

Linz prosecutors investigate deaths after Legionella outbreak

Prosecutors in Linz have opened an investigation on suspicion of negligent homicide following a Legionella outbreak in the greater Linz area, ORF Upper Austria reported on Tuesday. Thirty-two people contracted Legionnaires’ disease and three died. The investigation is against unknown perpetrators…

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Pedro Escoll

@pescoll.bsky.social

about 1 year ago

New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr

Figure 5. Working model for pathogen-specific ETC modulations that preserve the ∆ψm in hMDMs. (A) L. pneumophila: T4SS effectors dampen OxPhos early during
infection and preserve the ∆ψm by engaging the reverse mode of the FOF1 -ATPase. The ∆ψm remains high enough that ANT stays in forward mode, limiting cytosolic ATP
drain. All ETC complexes (I-IV) contribute to maintaining the ∆ψm. Complex I is uniquely essential during WT infection. (B) S. Typhimurium: T3SS SPI-1/2 effectors reduce
respiration and preserve the ∆ψm without inducing the reverse mode of the FO F1 -ATPase. Virulent bacteria rely on Complex I-driven electron entry with obligatory Complex
III/IV proton pumping, while Complex II contributes in all infection conditions. Secretion-defective mutants fail to establish the Complex I-dependent configuration.

bioRxiv Microbiology @biorxiv-microbiol.bsky.social

Complex-I Preserves Mitochondrial Polarization during Infection of Human Macrophages by Secretion-competent Bacteria https://www.biorxiv.org/content/10.1101/2025.09.04.674018v1

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PLOS Biology

@plosbiology.org

about 1 year ago

#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE

Top: HeLa cells expressing FLAGLpPIP, or FLAGRVxFdead were stained with 100 nM MitoTracker Deep Red FM (mitochondria; MTDR) and, following fixation, processed for immunofluorescence using antibodies against FLAG (green) and PPP1CB (magenta). Nuclei were stained with Hoechst 33258 (blue). Scale bar represents 10 μm. Fluorescence signal profiles of FLAG and PPP1CB were measured across the indicated line of interest. Bottom: AlphaFold3 structure of LpPIP-PPP1CB complex labeled with the active site (purple) and three substrate binding grooves (yellow) of PPP1CB.

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European Centre for Disease Prevention and Control

@ecdc.europa.eu

over 1 year ago

The six laboratories cover the following areas: ➡️ #AMR - #AntimicrobialResistance in bacteria ➡️ Vector-borne viral pathogens ➡️ Emerging, rodent-borne and zoonotic viral pathogens ➡️ High-risk, emerging and zoonotic bacterial pathogens ➡️ #Legionella ➡️ #Diphtheria and #pertussis

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Microbes.Info

@microbesinfo.bsky.social

9 months ago

www.nj.com

N.J. hospital warning hundreds of patients about a deadly bacteria found in its water

After a patient died with Legionnaires' disease, state testing found the dangerous bacteria lurking in the hospital's water system.

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Molecular Biology and Evolution

@molbioevol.bsky.social

about 1 year ago

Moreno, @lionelguy.bsky.social et al. applied experimental evolution to identify genes conferring host specificity to L. pneumophila, highlighting the importance of mutations targeting the LerC protein and the LPS synthesis cluster. 🔗 doi.org/10.1093/molbev/ms… #evolbio #molbio #legionella

doi.org

Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts

Abstract. Legionella pneumophila is an endosymbiotic bacterial species able to infect and reproduce in various protist and human hosts. Upon entry into hum

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Juha Haataja

@j11h11.bsky.social

8 months ago

Jätettääkö? "Hän epäilee, että tartunta oli peräisin aivan naapurissa sijaitsevasta Loviisan satamasta. Siellä säilytettiin ja käsiteltiin tuohon aikaan runsaasti ulkomailta tulleita jätepaaleja avonaisilla ulkoalueilla." #Loviisa #legionella yle.fi/a/74-20205287

yle.fi

Legionellabakteeri vei Jan-Erik Meriheinän hengityskoneeseen – perhe epäilee sataman roskavuoria tartunnan lähteeksi

Loviisalainen Jan-Erik Meriheinä sairastui vakavasti legionellaan. Hän epäilee tartunnan olevan peräisin satamaan tuoduista ulkomaisista jätepaaleista. Satama kiistää yhteyden.

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