Olivier Neyrolles

@oneyrolles.bsky.social

How cool! Amit Singh lab shows M. tuberculosis exploits macrophage metabolism to dodge drugs. Flipping macrophages from OXPHOS to glycolysis with FDA-approved meclizine subverts redox heterogeneity & cuts drug tolerance 🚀 #TBResearch #DrugResistance #MicroSky www.biorxiv.org/content/1….

0 8 31

Savitski Lab

@savitski-lab.bsky.social

6 months ago

Rewiring of oncogenic signaling in #DrugResistance is a moving target. In our new study, we used biophysical phosphoproteomics to investigate #BRAF mutant cancer, linking phosphorylation changes to protein function and #MolecularMechanisms through #Multi-Omics integration. tinyurl.com/funsignaling

1 12 29

Atanas G. Atanasov

@atanas-g-atanasov.bsky.social

12 months ago

🧵[1/6] A new hope against drug-resistant superbugs? Meet Saarvienin A! 🔗 inpst.net/superbug-sla... 🌐 #Antibiotics #DrugResistance #INPST @hipecsurvivor.bsky.social @shawneexo.bsky.social @martinbue.bsky.social @alisyngayle.bsky.social @holyunknown.bsky.social @gmpinglish.bsky.social

2 8 28

PLOS Biology

@plosbiology.org

about 1 year ago

#Fungal infections are hard to treat due to #DrugResistance. @blakebillmyre.bsky.social &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @plosbiology.org 🧪 plos.io/4dz3iVm

Schematic of TN-seq in C. neoformans. Top left: Transposon insertions (orange arrow) into nonessential genes results in viable cells. In contrast, insertions into essential genes will result in dead and nonrecoverable cells. Top right: TN-seq works by generating a library of cells where each cell has a single independent transposon insertion in a random location. As in A, those insertions into essential regions cause the cells to die and are nonrecoverable. As a result, the total library (bottom) is depleted in insertions in essential regions. Bottom: The Ac/Ds transposon was split into an Ac transposase and a Ds transposon containing a neomycin resistance marker. This Ds transposon was integrated into an intron of URA5 and the Ac transposase was integrated into the safe haven locus. The resulting stain is ura− and neomycin resistant. Upon initiating transposition via growth on galactose, the strain becomes URA+ and mutant at another locus (depicted here as YFG1).

1 10 19

John Ebos

@ebos.bsky.social

over 1 year ago

📣New paper from our lab published in @emboreports.bsky.social 📣 Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors @roswellpark.bsky.social @acscan.bsky.social #Cansky #oncosky #medsky #cancerresearch #drugresistance

www.embopress.org

Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors | EMBO reports

imageimageAcquired resistance to PD-L1 inhibition can rewire the interferon-regulated secretory machinery in tumor cells, altering the immune microenvironment. These secretory programs may be exploite...

1 1 18

PLOS Biology

@plosbiology.org

about 1 year ago

#Fungal infections are hard to treat due to #DrugResistance. @blakebillmyre.bsky.social &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @plosbiology.org 🧪 plos.io/4dz3iVm

1 5 17

TARGetAMR

@target-amr.bsky.social

over 1 year ago

The @ukri.org #TARGetAMR #Network is supporting #WHO: World #Antimicrobial #Resistance Awareness Week #WAAW2024 #AMR #Genomics #AMRAwareness #DrugResistance. Join us on our mission: targetamr.org.uk

0 10 16

Sara Gosline (she/her)

@sargoshoe.bsky.social

over 1 year ago

Love this! I'm at Pacific Northwest National Labs, and my #compbio goals focus on: 1. Building #computational models to characterize/treat #drugresistance in cancer 2. Ensuring we have good disease models to evaluate and test drug response in #cancer 3. Enabling AI by building AI-ready #data

0 3 15

PLOS Biology

@plosbiology.org

6 months ago

#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz

Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.

0 6 15

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 days ago

#Cancer #DrugResistance continues to limit therapeutic success. This review summarizes the molecular mechanisms driving drug response and resistance and discusses emerging strategies to improve treatment outcomes. #STTT #OpenAccess: doi.org/10.1038/s413...

Cancer drug response and resistance: molecular mechanisms and combating strategies

0 0 1

Frank Venter

@vfrank.bsky.social

over 2 years ago

#HiSciSky Happy to migrate over here. I'm a postdoc in Edinburgh, interested in #trypanosomes, #coinfection, and #drugresistance. I post mostly about science, but occasionally comment on politics that impact researchers (esp. from the Global South). T. brucei image: Sue Vaughan/ Welcome Collection

0 2 10

Plenty of Room - Newsletter

@plenty-of-room.bsky.social

about 1 year ago

Today, a great paper tackling a giant challenge: antibiotic resistance! A new type of antibiotics from @mcmasteruniversity.bsky.social and University of Illinois Chicago 🧪 😎 #drugs #drugresistance #biotech Get more like this at 👉 plentyofroom.beehiiv.com/….

plentyofroom.beehiiv.com

Lasso Peptide Antibiotics: A New Hope against Bacteria

Lasso peptides emerge as a promising solution to combat multi-drug resistant bacteria, offering innovative antibiotics through nature-derived products.

0 6 9

📊 User Rankings

📈 Bluesky Growth Stats

📰 Content Rankings

📚 Feed Tools & Insights

🛠️ Additional Tools & Resources

❓ Frequently Asked Questions

#DrugResistance

#DrugResistance posts per day (last 30 days)

Related tags

Posts with #DrugResistance

Explore trending tags