#antibiotic

1ban.news

Last-Resort Antibiotics Are Failing Sick Children, and the Trend Lines Point to 2035 - 1ban.news

Antibiotic resistance has usually been told as an adult story: children, the argument went, have robust immune systems and shorter exposure histories, so the crisis could wait. A new study in JAMA Pediatrics, built on more than 106,000 bacterial isolates from children in 82 countries collected over 19 years, says that comfort is misplaced: resistance

www.news-medical.net

NEWS2 score may improve antibiotic decisions in suspected sepsis

A study of nearly 100,000 adults treated for suspected infection suggests that the National Early Warning Score (NEWS2), a score based on routinely collected vital signs that is widely used to identify patients at risk of clinical deterioration, may help clinicians identify which patients are most likely to benefit from immediate antibiotic treatment and which may safely undergo further evaluation before receiving antibiotics. NEWS2 has been adopted by many healthcare systems internationally and is recommended in the United Kingdom to help guide the urgency of antibiotic treatment in suspected sepsis, but until now there has been little empirical evidence supporting this approach. The study, led by investigators from the Center for Sepsis Epidemiology & Prevention Studies (SEPSIS) at the Harvard Pilgrim Health Care Institute, appears in The Lancet Respiratory Medicine on August 5. Refining urgent treatment decisions in sepsis While timely administration of antibiotics is a cornerstone of sepsis care, diagnosing sepsis early can be complicated because its symptoms often overlap with many other serious medical conditions. Many patients treated for possible sepsis ultimately have non-infectious illnesses, exposing them to antibiotics that may offer limited benefit while increasing the risk of adverse effects and antibiotic overuse. Recognizing the need to...

fadic.net

Genomics in Antimicrobial stewardship

Genomics in Antimicrobial stewardship is in the race, but stewardship. Making the best use of current antibiotics to minimise the spread

sentientmedia.org

Scottish Salmon Relies on Antibiotics Not Approved by the FDA - and Rarely Tested for

A combination of mismatched regulations and inconsistent seafood testing is leaving U.S. consumers of farmed salmon imported from Scotland at risk of exposure to antibiotics not approved by the U.S. Food and Drug Administration (FDA), according to a U.K. report. Antibiotics are essential for preventing and treating diseases in farm animals, and there are strict FDA regulations for drugs used in fish raised for food. But these rules are different in other countries, such as Scotland, where some authorized compounds, such as quinolones, flumequine and oxolinic acid. Despite this, the FDA tests only one in every thousand seafood imports for the drugs and rarely follows through with enforcement, according to an audit by the U.S. Government Accountability Office. The overuse of antibiotics in aquaculture poses a concern to consumers — who risk eating pathogens that have grown resistant to antibiotic treatments in the salmon — and to global public health. Jennifer Ronholm became a research chair in agricultural microbiology at McGill University after stints with Health Canada and the Canadian Food Inspection Agency, and says antimicrobial resistance is an underappreciated risk to human life. “If we can’t treat these infections anymore, things that we kind of take for granted now...

www.nih.gov

Bacteria share proteins to survive antibiotics

Researchers found that some bacteria share proteins that help others survive antibiotics.

pmc.ncbi.nlm.nih.gov

Antibacterial Activity of Colloidal Silver against Gram-Negative and Gram-Positive Bacteria

Due to the emergence of antimicrobial resistance, new alternative therapies are needed. Silver was used to treat bacterial infections since antiquity due to its known antimicrobial properties. Here, w...

scitechdaily.com

Scientists Turn an Old Antibiotic Back Into a Superbug Killer

A small molecule restored vancomycin’s activity against resistant bacteria by blocking a key bacterial enzyme. A trusted antibiotic can lose its power when bacteria evolve ways to resist it. As this problem spreads, infections that were once manageable can become dangerous, while routine surgery and cancer treatment carry greater risks because antibiotics may no longer prevent or control infection. Researchers are therefore looking beyond the traditional search for entirely new antibiotics. One alternative is to pair existing drugs with antibiotic adjuvants, compounds that do not directly kill bacteria but instead disable the defenses that make the microbes resistant. Existing antibiotics gain new partners John Moses and his colleagues at Cold Spring Harbor Laboratory (CSHL) have spent years developing chemical reactions that make it faster and easier to create potential drug molecules. Their work includes a method called diversity-oriented clicking (DOC), which was developed in the Moses laboratory. Using this approach, researchers assembled a library containing more than 150 compounds with varied molecular structures. That collection has already supported research into both antibiotic resistance and cancer. A collaboration with Scripps Research has now used the library to restore the effectiveness of vancomycin, an important antibiotic used against serious infections, including those...