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Could Genetically Engineered Fungus Help Replace Animal Protein?
Microscopic fungi haven’t seemed like a scalable alternative to meat. CRISPR could change that.
A Medsky Topics feed composed of posts covering recent news related to the gene-editing technology, CRISPR Powered by @medsky.social
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🎧 Episode 3 of The Future of Medicine is now LIVE, featuring Jennifer Doudna, a Nobel laureate, pioneer of #CRISPR gene editing & one of the most influential scientists of our time. Watch on our YouTube or stream here (bit.ly/4rQmq85) or anywhere you listen to podcasts!
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Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells www.biorxiv.org/content/1…
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Coming next week on The Future of Medicine: Jennifer Doudna, a Nobel Prize–winning biochemist & the co-inventor of CRISPR gene editing! #StanDOM's @euanashley.bsky.social & Doudna discuss scientific curiosity, responsible innovation, gene editing & more. bit.ly/43LGRZv
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As Dimitrios A. Garyfallos shares new findings on, “In vivo CRISPR/Cas9 genetic screens identify novel immunotherapy target” at #ESMOImmuno25, discover more on CRISPR with #JITC!
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For readers interested in genome editing therapeutics, this Review in the December issue discusses progress in the application of CRISPR-based genome editing to treat inherited blood disorders such as sickle cell disease
rdcu.be/eTR9i
www.nature.com/articles/s41...
rdcu.be
CRISPR-based therapeutic genome editing for inherited blood disorders
Nature Reviews Drug Discovery - CRISPR-based technologies provide a diverse set of tools to correct pathogenic mutations. This Review describes the promise and the challenges of genome editing...
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More research from #MuschenLab: CRISPR screens uncover a B-cell–selective pathway that degrades β-catenin through NAE1. This suggests existing NAE1 inhibitors—alone or with GSK3B blockers—could be repurposed for B-cell cancers. #ASH25 @yale-hematology.bsky.social @oncoalert.bsky.social
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As the year ends, we’re highlighting hematology innovations. A 13-year follow up showed gene therapy for hemophilia B remains safe & effective, while a study on CRISPR-based epigenetic editing reactivated fetal hemoglobin for sickle cell & beta-thalassemia.
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CRISPR-Cas9 Gene Editing of ANGPTL3 Reduces Protein Levels Up to 80% Without Dose-Limiting Toxicity in Phase 1 Trial.
by Laffin LJ, Nicholls SJ (...) Nissen SE et 11 al. in N Engl J Med #MedSky
👉 get more here
📖 read the article: www.nejm.org/doi/10.1056/…
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It’s almost the best part of the week: Friday Afternoon Seminars!
Can’t wait to learn about the latest research from Changkun Hu in the @suebiggins.bsky.social Lab and Haolong Li from the Human Biology Division. For all our @FredHutch.org colleagues, join us in Pelton at 4PM for two great talks!
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A tailored in vivo CRISPR screen identifies BAP1 as a potent tumor suppressor of soft tissue sarcoma www.biorxiv.org/content/1…
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Scientists grew a microscopic fungus into a more efficient — and meat-like — edible protein by tweaking just two genes with CRISPR gene editing.
buff.ly
Could Genetically Engineered Fungus Help Replace Animal Protein?
Microscopic fungi haven’t seemed like a scalable alternative to meat. CRISPR could change that.
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This should get more attention than the football team, but I know it won’t
www.cbsnews.com/news/teen….
www.cbsnews.com
Teens may have come up with a new way to detect, treat Lyme disease using CRISPR gene editing
To compete at iGEM, a sort of science Olympics, teens at a Georgia high school set their sights on finding a better way to detect and treat Lyme disease. Their approach uses CRISPR gene editing.
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Microscopic fungi haven’t seemed like a scalable alternative to meat. CRISPR could change that. Alexandra Tey reports:
buff.ly/9EcGuR8
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Our December issue is live! Read about how multispecific molecules are transforming pharmacotherapy, CRISPR-based genome editing for blood disorders, advances in the treatment of lupus, progress with small-molecule kinase inhibitors and more here www.nature.com/nrd/volumes/...
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Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes Recapitulates Molecular and Morphological Features of High-Risk Endometrial Cancer www.biorxiv.org/content/1…
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Our final issue of 2025 has gone live!
🫁pertussis prevention
🏭pollutants and gut bacteria
🕳️porins and resistance in E. coli
🧬many flavours of CRISPR
🦟fatal fungal attraction
...and more 👇
www.nature.com/nmicrobiol/v...
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Remarkable story of a Georgia high school team who used CRISPR to make a rapid diagnostic test strip for Lyme disease, speeding dx from 2 weeks to days
www.cbsnews.com/news/teen….
www.cbsnews.com
Teens may have come up with a new way to detect, treat Lyme disease using CRISPR gene editing
To compete at iGEM, a sort of science Olympics, teens at a Georgia high school set their sights on finding a better way to detect and treat Lyme disease. Their approach uses CRISPR gene editing.
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CRISPR-Cas?associated SCCmec variants in methicillin-resistant Staphylococcus aureus evade rapid diagnostic detection
✅ Just Accepted
🔗 bit.ly/3LWRti0
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To compete at iGEM, a worldwide synthetic biology competition, teens at an Atlanta high school set their sights on finding a better way to detect and treat Lyme disease using CRISPR gene editing. This Sunday, Bill Whitaker reports on their project, which could be a major scientific breakthrough.
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CRISPR-Edited, Immunosuppression-Free Islet Transplantation for Type 1 DIabetes: First-in-Human Study
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #CRISPR #DIabetes
oncodaily.com
CRISPR-Edited Islet Transplant Shows Immune Silence
CRISPR-edited islet transplant cells function without immunosuppression, showing immune silence and glucose-responsive insulin secretion.
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#NatMicroPicks
Editing gut microbiota in vivo! 🔧🧬🦠
MetaEdit enables precise in vivo CRISPR-based editing of native gut bacteria, integrating new pathways at single-nucleotide resolution
#MicroSky #SynBio
www.science.org/doi/10.11….
www.science.org
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
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America’s next wave of scientific talent may come from Lambert High School, where students used CRISPR to develop a promising new way to detect and treat Lyme disease. This Sunday, Bill Whitaker follows the students as they compete in a prestigious international science competition. 60Minutes.com
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