dlvr.it
Advancing the Science of #patient Input in Drug Research and Development
The integration of #patient input into drug research & development (R&D) enables the production of medicines that better meet the needs of #patients. While momentum for advancing the science of #patient input has continued to grow, there remain a host of barriers to full implementation and integration of systematic approaches for collecting and using robust and meaningful #patient input data to inform decision-making. To help address these barriers, the Advancing the Science of #patient Input Action Collaborative (the collaborative), an activity associated with the National Academies of Sciences, Engineering, and Medicine (National Academies) Forum on Drug Discovery, Development, and Translation, organized a multi-stakeholder endeavor to identify and address key barriers to implementation through a series of information-gathering efforts. The collaborative engaged a wide range of perspectives to seek out practical paths forward to better align drug discovery, development, and regulation with #patient priorities for disease management and treatment. Collaborative #participants focused on three overarching research priorities which, if effectively addressed, would help advance the science of #patient input: 1) understanding the #patient experience over the course of a given disease or medical condition, 2) capturing the #patient perspectives and priorities on benefit-risk, and 3) incorporating #patient input into clinical trial design and continuous improvement. Addressing these research priorities would help decision makers shift away from using #patient input in particular cases or for one-off applications and towards the integration of #patient input as part of everyday medical research and practice. Building upon existing guidances and strategies, and sharing lessons learned from use cases, a comprehensive #patient input framework would serve as a critical step towards reimagining and enriching the science of #patient input throughout the drug R&D process, enabling a future in which medicines more fully meet the needs of #patients.