www.nature.com
The IDEAL framework for machine perfusion in liver transplantation
Nature Reviews Gastroenterology & Hepatology, Published online: 16 June 2025; doi:10.1038/s41575-025-01085-5Liver transplantation is challenged by organ scarcity and ageing donors. Machine perfusion is a promising technique to enhance organ preservation and assessment, improving liver utilization and patient outcomes. Here, we discuss current practices in machine perfusion using the IDEAL framework and outline the steps needed to advance this technology clinically.