C.H. Romatowski 
www.nature.com
Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier
CRISPR-based tools canāt easily access the DNA in these organelles, but researchers are finding other ways in.
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The Birmingham Evening Mail, England. 16th October 1998. #mecfs #myalgicencephalomyelitis #myalgice #cfsme
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The Black Country Evening Mail, England. 16th October 1998. An editorial on a boy whose care was the subject of a legal battle in Solihull (England) in 1998. #cfsme #mecfs #myalgicencephalomyelitis #myalgice
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New from Nature: Scientists are learning to fix faulty mitochondrial DNA, offering hope for rare genetic diseases.
While not specific to #MECFS, it's a big step for understanding energy metabolism, something long suspected to play a role in ME/CFS.
š www.nature.com/articles/d41...
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Yeah, another key feature to this denial is pretending the worlds didnāt change with the advent of covid, or that itās gone back to exactly how it was before. Like pretending a volcano hasnāt gone off and that lava in your yard is just a new kind of plant.
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There are excellent complex conversations about how best to push for Covid mitigations and goals and science between Covid Conscious people every day. But these are people who have decided not to mask, have a smidgen of awareness or shame about it, and desperately need a way to prove itās fine.
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This is not a good faith ask about the current science on Covid, or masking best practices, or how to implement safety, or how to best protect vulnerable people, any more than a child saying āSO I GUESS I SHOULD JUST STAY IN MY ROOM FOREVER, HUH??ā
The use of forever gives away the game here.
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This is a rhetorical trap. If you say āyes, the best practice would be for everyone to mask until we have better vaccines and treatments for long covidā they will either say HA! SEE YOURE CRAZY! Or āwell no one wants to mask forever, so you should just give upā
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Masks do not block airways, and he does not wear one at home because heās not exposed to the public at home, although he did wear one 24/7 when I had Covid, and did not get it as a result.
Are you hitting the bottom of the barrel any time soon? Because your arguments truly canāt get much sillier.
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A #JohnVsJonVsME @johnvsjonvsme.bsky.social #GreatestMEdicalScandal #Halloween MEme I made last year about this ignored horror (and how itās my villain origin story) @juliadoubleday.bsky.social @ryankenacts.bsky.social @johngreensbluesky.bsky.social @markruffalo.bsky.social
My spirit is tired š
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Inhibition of allergic & non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists
pubmed.ncbi.nlm.nih.gov/6ā¦
Off label, theyre also sometimes used for Raynaud's and psychiatric conditions like bipolar disorderāboth may also have mast cell involvement
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Adding also the horror of using nonrenewable financial/social resources (and trial & error & luck) to find a treatment that helps #ME #POTS #MCAS etc (to add 5% QOL) to have it all blown away by another COVID infection. @johngreensbluesky.bsky.social @hankgreen.bsky.social @markruffalo.bsky.social
Julia Doubleday@juliadoubleday.bsky.social
People continue to call COVID advocatesā pleas for masking āunreasonableā. Yet people whoāve already been disabled by COVID have no choice but to live with the āunreasonableā burdens of constant COVID safety. My latest: substack.com/home/post/p-...
substack.com
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Effect of antihypertensive treatment with valsartan or atenolol on sexual activity & plasma testosterone in hypertensive men
pubmed.ncbi.nlm.nih.gov/1ā¦
"Testosterone was reduced by atenolol (from 18.2 to 13.8 nmol/l) but was not affected by valsartan (from 17.6 to 18.3 nmol/l)"
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Beta blockers may reduce testosterone:
Beta-blocker effects on sexual function in normal males
pubmed.ncbi.nlm.nih.gov/2ā¦
Total and free testosterone reduced with atenolol, metoprolol, pindolol, and propranolol, more so with the latter two as non-selective drugs
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A balm of a text re. whatās reasonable & unreasonable and on the absurd burden (& criticism) upon those of us harmed/devastated & following the science of COVID and #LongCovid. Gracias, Julia
@ryankenacts.bsky.social @johngreensbluesky.bsky.social @hankgreen.bsky.social
@markruffalo.bsky.social
Julia Doubleday@juliadoubleday.bsky.social
People continue to call COVID advocatesā pleas for masking āunreasonableā. Yet people whoāve already been disabled by COVID have no choice but to live with the āunreasonableā burdens of constant COVID safety. My latest: substack.com/home/post/p-...
substack.com
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Itās unfortunate and makes COVID incredibly difficult to control - symptomatic measures alone cannot properly mitigate at a population level. The govts decision not to communicate this information well is downstream of their unwillingness to institute interventions like clean air & far UVC
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I surely do! Estimated vary study to study, but this review and meta-analysis found āthe proportion of people who became infected with SARS-CoV-2 and remained asymptomatic throughout infection was 44.1%ā
pmc.ncbi.nlm.nih.gov/artiā¦.
pmc.ncbi.nlm.nih.gov
Asymptomatic SARS-CoV-2 Infection by Age: A Global Systematic Review and Meta-analysis
Asymptomatic SARS-CoV-2 infections have raised concerns for public health policies to manage epidemics. This systematic review and meta-analysis aimed to estimate the age-specific proportion of asympt...
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A discussion about friendship and ME
meglobalchronicle.wordpreā¦.
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
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11/22/21, Medical News Today: 'Through my eyes: Long neuro-COVID'
'My heart rate would increase further, to 170 bpm, on standing and with minimal exertion, such as getting a drink or using the bathroom.'
'I havenāt watched TV or driven in 10 months.'
www.medicalnewstoday.com/ā¦.
www.medicalnewstoday.com
My experience of living with long neuro-COVID
Dr. Kelly Ann Fearnley lives with long COVID and persistent neurological and neurocognitive symptoms. In this article, she talks about her experiences.
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Then my husbandās āfriendsā would mock him with texts like āwhat, are you all afraid of the sniffles now?ā
Meanwhile at home heās watching me deteriorate every year until Iām housebound and 97% bedbound from #MECFS
He dropped them.
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I can elaborate a little (knowing some of these folks might be reading)... it went both ways, with even well-meaning people still expecting me to meet at bars inside and feeling bad about them not getting it, and some people who, after I just mentioned long Covid, ghosted, and it's been years
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Excellent piece.
Every time this discourse rolls around they treat those of us that mask like weāre hypochondriacs.
No weāre the ghosts of infections past.
We plead with you so that you can avoid our fate. In return you mock us.
#MECFS #LongCovid
Julia Doubleday@juliadoubleday.bsky.social
People continue to call COVID advocatesā pleas for masking āunreasonableā. Yet people whoāve already been disabled by COVID have no choice but to live with the āunreasonableā burdens of constant COVID safety. My latest: substack.com/home/post/p-...
substack.com
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