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Comparison of three temperate rainforest climate envelopes for Britain and Ireland: Where could our rainforest be?

There are multiple methods for creating climate envelopes for temperate rainforest, and these climate envelopes result in different extents across Ireland and Britain. An awareness of these differenc...

physicsworld.com

Implanted electrodes provide intuitive control of prosthetic hand – Physics World

Signals recorded by implanted electrodes enable accurate prosthetic control of hand and wrist movements under real-world conditions

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Seasonality controls the vegetation of a late Middle Miocene forest in Europe

The Miocene was a past warm interval considered highly relevant to future climate projections. Whilst temperatures during the Miocene were constrained by multiple proxies, the hydrology of the Miocene...

doi.org

Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates | Nature Chemical Biology

The post-translational modification (PTM) of proteins by O-linked β-N-acetyl-D-glucosamine (O-GlcNAcylation) is widely found across the proteome and regulates diverse cellular processes, from transcription and translation to signal transduction and metabolism. However, most functional studies to date have focused on individual modifications, overlooking other simultaneous O-GlcNAcylation events that work together to coordinate cellular activities. Here we describe networking of O-GlcNAc transferase interactors and substrates (NOTISE), a systems-level approach that monitors O-GlcNAcylation rapidly and comprehensively across the proteome to reveal important functional and regulatory relationships. The NOTISE method integrates affinity purification–mass spectrometry and site-specific chemoproteomic technologies with network generation to connect putative upstream regulators and downstream targets of O-GlcNAcylation. The resulting data-rich networks identify critical conserved activities o

doi.org

In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogen | Nature Communications

Disruption of host cell barriers is a fundamental strategy enabling pathogens to establish a paracellular infection. Here, using dual RNA-Seq, we determine the in vivo host-pathogen transcriptomic landscape upon infection by the extracellular pathogen Leptospira interrogans and uncover a mechanism of cell–cell junction disruption. We demonstrate that, upon infection, an increase in intracellular calcium triggers tight junction destabilization, by activating the calmodulin and myosin light chain kinase signalization. We identify two bacterial effectors of the Virulence-Modifying (VM) proteins family, structurally related to toxin-like proteins, that promote modulation of calcium homeostasis and disruption of cell–cell junctions, thereby allowing Leptospira translocation across epithelium barriers, tissue colonization and pathogenicity. Furthermore, we demonstrate that at least one of these VM proteins is secreted and associates with host cells. Altogether, these findings reveal a unique strategy by which an extracellular pathogen secretes toxin-like proteins to exploit host calcium signaling for breaching epithelial barriers. Here, the authors use in vivo dual RNA sequencing to determine the host-pathogen transcriptomic landscape upon infection by Leptospira interrogans, revealing alterations in pathways associated with paracellular permeability, like cell–cell junctions.

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Uncovering what shapes the spatial distribution of a key phosphorus-cycling gene (PhoD) in tropical and subtropical forests

Sandhya Mishra, Shangwen Xia, Wenting Wang, Xiaodong Yang This is a plain language summary of a Functional Ecology reseacrh article which can be found here. Phosphorus is an essential nutrient, cri…

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Accelerating dataset generation for machine learning using large language models: a pharmaceutical additive manufacturing case

Creating high-quality datasets for training machine learning models in specialized domains like pharmaceutical research is often constrained by the ma…

grrlscientist.medium.com

MRI Scans Reveal Mothers Build Their Children’s Brains Long After Birth —  In Horses

Many people believe that as soon as a foal can survive without milk, it’s ready to be weaned, usually between 4 and 6 months of age…

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From Stockholm to Baltimore: multimorbidity biomarkers confirmed in the NIH-led Baltimore Longitudinal Study of Aging

A single chronic diagnosis is rarely the end of the story for older adults. Hypertension may be followed by diabetes, then kidney strain, then cardiovascular complications — or a very […]