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Gut microbiota and metabolites drive chronic sickle cell disease pain in mice
Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...
www.sciencedirect.com
Gut microbiota and metabolites drive chronic sickle cell disease pain in mice
Individuals with sickle cell disease (SCD) suffer from debilitating chronic pain that does not have a clear etiology. Recent 16S ribosomal RNA gene se…
www.sciencedirect.com
Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain
Neuropathic pain remains a challenging clinical condition due to its resistance to conventional analgesics. The purinergic P2X4 receptor (P2X4R), an A…
www.nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
bpspubs.onlinelibrary.wiley.com
BPS Publications
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene-related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ recep...
www.nature.com
Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications
Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...
journals.lww.com
SARS-CoV-2 N protein interacts with Nav1.7 to promote... : PAIN
ong COVID sequelae. The mechanisms underlying somatosensory abnormalities induced by SARS-CoV-2 remain largely unclear. In this study, we investigate the role of the SARS-CoV-2 nucleocapsid (N) protei...
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The gut microbiota promotes pain in fibromyalgia
Cai et al. revealed that transplanting gut microbiota from women with fibromyalgia—a chronic widespread pain condition of unknown etiology—into mice induces pain. It also induces phenotypes commonly o...
www.nature.com
Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications
Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...
www.nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
journals.lww.com
Individual differences in conditioned pain modulation are... : PAIN
we examined the relationship between CPM and peak alpha frequency (PAF) and power in the dynamic pain connectome (DPC). In 68 healthy individuals who underwent resting-state magnetoencephalography and...
journals.lww.com
A combined activity of peripheral nociceptive and... : PAIN
eptors. Using electrical and optogenetic approaches, we selectively activated different fiber subtypes without causing neuronal injury. Our findings demonstrate that only simultaneous activation of bo...
journals.lww.com
Salience or value: what drives priority in pain–cognition... : PAIN
have yet to discover how priority is assigned when pursuing competing goals while experiencing pain: through attentional resource competition (salience-based) or motivational conflict (value-based), o...
@mheming.bsky.social
Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies. Explore: pns-atlas.mzhlab.com A tweetorial 1/13 doi.org/10.1038/s414...
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Autoantibodies as drivers of neuropathic pain
Emerging evidence, supported by clinical responses to immunotherapy and the recapitulation of sensory symptoms in passive transfer models, shows that autoantibodies (AAbs) may drive neuropathic pain. ...
www.nature.com
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Activity-dependent development of the body’s touch receptors
Santiago et al. report that the mechanosensitive ion channel Piezo2 is required for the transcriptional and structural maturation of the primary sensory neurons that detect gentle touch and that Piezo...
www.science.org
Driven by the pain of endometriosis, this scientist is uncovering clues to its causes
Katie Burns is helping reveal the immune system’s role in the long-neglected disease
www.nature.com
Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons - Communications Biology
Single cell RNA-sequencing, spatial transcriptomics and chromatin analyses of sensory neurons provide insights into cell type organization of the dorsal root ganglion and the enhancer-driven co-regula...
journals.sagepub.com
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
www.pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.science.org
Differential encoding of mammalian proprioception by voltage-gated sodium channels
Voltage-gated sodium channels differentially encode mammalian proprioception via distinct cellular localization patterns.
www.science.org
Synaptic architecture of a memory engram in the mouse hippocampus
Memory engrams are formed through experience-dependent plasticity of neural circuits, but their detailed architectures remain unresolved. Using three-dimensional electron microscopy, we performed nano...
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Human pain neuroscience and the next generation of pain therapeutics
The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies p...
