www.sciencedirect.com
Gut microbiota and metabolites drive chronic sickle cell disease pain in mice
Individuals with sickle cell disease (SCD) suffer from debilitating chronic pain that does not have a clear etiology. Recent 16S ribosomal RNA gene se…
bioRxiv Neuroscience@biorxiv-neursci.bsky.social
Discrete and sequential critical periods organise the development of task-specific sensorimotor circuits in mice https://www.biorxiv.org/content/10.1101/2025.09.18.676788v1
www.science.org
Ethanol ingestion via frugivory in wild chimpanzees
Natural daily consumption of dietary alcohol by chimpanzees suggests human attraction to alcohol may come from our ancestral diet.
www.biorxiv.org
PIEZO channels link mechanical forces to uterine contractions in parturition
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...
www.sciencedirect.com
Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain
Neuropathic pain remains a challenging clinical condition due to its resistance to conventional analgesics. The purinergic P2X4 receptor (P2X4R), an A…
public health guy@publichealthguy1.bsky.social
just a casual reminder to those outside public health that RFK Jr. didn’t repair CDC’s offices before forcing staff to return monday because he wants the damage to intimidate and traumatize federal workers
Osteoarthritis and Cartilage Journal@oacjournal.bsky.social
📢 Call for Papers OAC is excited to announce a Special Issue on Pain Mechanisms in Osteoarthritis. www.sciencedirect.com/special-issu... Submission Deadline: May 15th, 2026
www.cell.com
Gut microbiota and metabolites drive chronic sickle cell disease pain in mice
Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...
www.nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.statnews.com
FDA leaders moving to abandon advisory committee reviews of specific new drugs
FDA leaders under President Donald Trump are moving to abandon a decades-old policy of asking outside experts to review drug applications
